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New Hope for Alzheimer’s Patients: Health Canada Approves First Disease-Modifying Treatment
Health Canada has granted conditional approval for LEQEMBI® (lecanemab), a groundbreaking therapy shown to slow the progression of early Alzheimer’s disease. Developed by Eisai Co., Ltd. and Biogen Inc., the drug is the first in Canada to directly target one of the underlying causes of the disease by reducing amyloid-beta aggregates in the brain.
LEQEMBI is authorized for adults diagnosed with mild cognitive impairment or mild dementia due to Alzheimer’s disease, specifically for patients who are apolipoprotein E ε4 (ApoE ε4) non-carriers or heterozygotes with confirmed amyloid pathology.
The approval follows results from the global Clarity AD Phase 3 trial, which demonstrated that lecanemab significantly slowed cognitive and functional decline compared to placebo. This milestone offers new hope to the more than 771,000 Canadians currently living with dementia, a number projected to rise to 1 million by 2030.
While the approval comes with conditions requiring further data, experts say this marks a pivotal step in shifting Alzheimer’s treatment from symptom management to disease modification.
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