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Evacuation in the Snow: Fears of Conflict Drive Mass Exodus from Pakistan’s Tirah Valley

Residents from Tirah valley, who fled a remote mountainous region bordering Afghanistan, gather to get themself registered, in Bara, Khyber District of Khyber Pakhtunkhwa province, Pakistan A wave of displacement is sweeping through northwest Pakistan as thousands of families flee the Tirah Valley after mosque loudspeakers warned residents of possible upcoming military action. The sudden announcements triggered a rapid and chaotic departure, with many families leaving in the middle of harsh winter conditions. Residents describe a tense atmosphere in the valley, where fears of renewed conflict between security forces and militant groups have been simmering for months. Entire communities have packed their belongings onto trucks, donkeys, and makeshift carts, heading toward safer towns such as Bara and Peshawar. Government officials insist that no military operation has been ordered and attribute the movement of people to seasonal migration patterns. Locals strongly dispute this, sayi...
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Alzheimer’s vaccines get a boost from new drug approval

 

After decades of disappointment and controversy, the field of Alzheimer’s disease research has finally seen a breakthrough with the approval of the first drug that targets the underlying pathology of the condition. 

Aducanumab, a monoclonal antibody that clears amyloid plaques from the brain, was granted accelerated approval by the US Food and Drug Administration in June 2021, despite mixed results from clinical trials and objections from some experts. 

The drug’s approval has rekindled interest in other therapeutic approaches that aim to prevent or slow down the progression of Alzheimer’s, such as vaccines that stimulate the immune system to attack amyloid or tau, another protein that accumulates in the brains of people with the disease. 

Several vaccine candidates are currently in various stages of development and testing, and some researchers are optimistic that they could offer a more effective and convenient way to treat Alzheimer’s than infusions of antibodies.


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