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Channel Tunnel Chaos Enters Day Two as Power Fault Drags On

The disruption, caused by a fault in the system's overhead power supply, on Tuesday upended plans for thousands of passengers in London, Paris, Brussels and Amsterdam. Rail passengers travelling between the UK and mainland Europe are enduring a second day of major disruption after a power failure shut down the Channel Tunnel, halting both Eurostar and LeShuttle services. The fault, linked to the overhead power supply, brought traffic to a standstill and left thousands of travellers stranded on both sides of the Channel. Although some services have begun to move again, operators warn that delays and cancellations will continue while engineers work to stabilise the system. Eurostar has urged passengers to avoid travelling unless essential, as many trains remain suspended or heavily delayed. LeShuttle customers are also facing long queues, with significant backlogs reported at both Folkestone and Calais. The timing has added to the frustration, hitting one of the busiest travel per...
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Alzheimer’s vaccines get a boost from new drug approval

 

After decades of disappointment and controversy, the field of Alzheimer’s disease research has finally seen a breakthrough with the approval of the first drug that targets the underlying pathology of the condition. 

Aducanumab, a monoclonal antibody that clears amyloid plaques from the brain, was granted accelerated approval by the US Food and Drug Administration in June 2021, despite mixed results from clinical trials and objections from some experts. 

The drug’s approval has rekindled interest in other therapeutic approaches that aim to prevent or slow down the progression of Alzheimer’s, such as vaccines that stimulate the immune system to attack amyloid or tau, another protein that accumulates in the brains of people with the disease. 

Several vaccine candidates are currently in various stages of development and testing, and some researchers are optimistic that they could offer a more effective and convenient way to treat Alzheimer’s than infusions of antibodies.


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